TL-21-3FD45C SYGNOMICS Report
01/09/2022
SOC Drugs
# 1. Target: GSR
Drugs
Model Evidence
7 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
Drugs in GBM Trials
# 1. Target: RRM2
Drugs
Model Evidence
12 regulons containing the target(s), RRM2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
2. Target: FNTA,FNTB
Drugs
Model Evidence
13 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
3. Target: ALDH5A1
Drugs
Model Evidence
1 regulons containing the target(s), ALDH5A1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
4. Target: JAK1,JAK2
Drugs
Model Evidence
21 regulons containing the target(s), JAK1,JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
FDA Approved Drugs
# 1. Target: MAOB
Drugs
Model Evidence
3 regulons containing the target(s), MAOB are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
2. Target: ALDH5A1
Drugs
Model Evidence
1 regulons containing the target(s), ALDH5A1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
3. Target: RPE65
Drugs
Model Evidence
3 regulons containing the target(s), RPE65 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
4. Target: JAK1
Drugs
Model Evidence
4 regulons containing the target(s), JAK1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
5. Target: HBB
Drugs
Model Evidence
2 regulons containing the target(s), HBB are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
6. Target: VKORC1
Drugs
Model Evidence
2 regulons containing the target(s), VKORC1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
7. Target: GSR
Drugs
Model Evidence
7 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
8. Target: ABL1
Drugs
Model Evidence
5 regulons containing the target(s), ABL1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
9. Target: MAPK10
Drugs
Model Evidence
2 regulons containing the target(s), MAPK10 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
10. Target: RTN4
Drugs
Model Evidence
3 regulons containing the target(s), RTN4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
11. Target: FGF1
Drugs
Model Evidence
1 regulons containing the target(s), FGF1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
12. Target: LOXL2
Drugs
Model Evidence
1 regulons containing the target(s), LOXL2 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
13. Target: BSG
Drugs
Model Evidence
2 regulons containing the target(s), BSG are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
14. Target: NDUFA13
Drugs
Model Evidence
5 regulons containing the target(s), NDUFA13 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
15. Target: TSG101
Drugs
Model Evidence
2 regulons containing the target(s), TSG101 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
16. Target: ITGA2
Drugs
Model Evidence
1 regulons containing the target(s), ITGA2 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_COAGULATION HALLMARK_APICAL_JUNCTION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
17. Target: NQO1
Drugs
Model Evidence
2 regulons containing the target(s), NQO1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
18. Target: PLA2G2A
Drugs
Model Evidence
2 regulons containing the target(s), PLA2G2A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
19. Target: ELN
Drugs
Model Evidence
1 regulons containing the target(s), ELN are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
20. Target: F8
Drugs
Model Evidence
2 regulons containing the target(s), F8 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
21. Target: TRPV4
Drugs
Model Evidence
1 regulons containing the target(s), TRPV4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
22. Target: MAPK1,MAPK3
Drugs
Model Evidence
19 regulons containing the target(s), MAPK1,MAPK3 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
23. Target: ABAT
Drugs
Model Evidence
16 regulons containing the target(s), ABAT are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
24. Target: RRM2
Drugs
Model Evidence
12 regulons containing the target(s), RRM2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
25. Target: EEF2
Drugs
Model Evidence
10 regulons containing the target(s), EEF2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
26. Target: TNC
Drugs
Model Evidence
9 regulons containing the target(s), TNC are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
27. Target: HSPA8
Drugs
Model Evidence
27 regulons containing the target(s), HSPA8 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
28. Target: ATP1A1
Drugs
Model Evidence
67 regulons containing the target(s), ATP1A1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_UV_RESPONSE_DN HALLMARK_TGF_BETA_SIGNALING HALLMARK_APOPTOSIS
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
29. Target: PLA2G2A,PLA2G5
Drugs
Model Evidence
7 regulons containing the target(s), PLA2G2A,PLA2G5 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
30. Target: JAK1,JAK2
Drugs
Model Evidence
21 regulons containing the target(s), JAK1,JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
31. Target: SLC6A9
Drugs
Model Evidence
13 regulons containing the target(s), SLC6A9 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
32. Target: CA2
Drugs
Model Evidence
13 regulons containing the target(s), CA2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
33. Target: FNTA,FNTB
Drugs
Model Evidence
13 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
34. Target: JAK2
Drugs
Model Evidence
17 regulons containing the target(s), JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
35. Target: SOD1
Drugs
Model Evidence
5 regulons containing the target(s), SOD1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
36. Target: ACVR2B
Drugs
Model Evidence
5 regulons containing the target(s), ACVR2B are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
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